Sermorelin, Ipamorelin, and CJC-1295 are peptide therapies that have gained popularity among athletes and individuals seeking anti-aging benefits. Each compound works by stimulating growth hormone release through different mechanisms, yet they share similar dosing schedules and side-effect profiles. The following guide covers typical dosages, price ranges for high-quality products, and a key safety reminder that should be heeded before beginning any peptide protocol.
Sermorelin
Sermorelin is an 8-amino acid analogue of growth hormone-releasing hormone (GHRH). It binds to the GHRH receptor on pituitary cells, prompting them to release endogenous growth hormone and subsequently insulin-like growth factor-1 (IGF-1). Because it stimulates natural production rather than delivering exogenous hormone directly, sermorelin is often preferred for its lower risk of hormonal imbalance.
Typical dosing:
0.2 mg per injection, administered once or twice daily.
Injections are usually given subcutaneously at bedtime to mimic the body’s natural nighttime surge in growth hormone.
A common protocol uses 0.2 mg two times per day for 12 weeks, followed by a break of 4–6 weeks before restarting if desired.
Ipamorelin
Ipamorelin is a selective ghrelin receptor agonist that specifically increases the release of growth hormone without affecting cortisol or prolactin levels. It is praised for its mild side-effect profile and high specificity, making it an attractive option for those concerned about potential hormonal side effects.
Typical dosing:
0.1 mg per injection, administered three times daily (morning, midday, evening).
Some users prefer a single 0.3 mg dose in the morning to reduce injection frequency while maintaining efficacy.
A standard regimen is 0.1 mg three times per day for 12 weeks, with periodic monitoring of IGF-1 and growth hormone levels.
cjc 1295 ipamorelin vs sermorelin-1295 (with DAC)
CJC-1295 is a long-acting analogue of GHRH that contains a directed alanine cleavage sequence (DAC). The DAC prolongs the peptide’s half-life to roughly 3–4 days, allowing for less frequent dosing while maintaining steady growth hormone stimulation.
Typical dosing:
0.1 mg per injection, administered once or twice weekly.
Many protocols use 0.2 mg weekly, split into two 0.1 mg injections on non-consecutive days.
A typical cycle involves 4–6 weeks of weekly dosing followed by a rest period of 3–5 weeks.
Pricing
The cost for each peptide varies widely based on purity, supplier reputation, and whether the product is sourced from reputable manufacturers or generic compounding pharmacies.
Sermorelin: Prices range from $60 to $120 per vial (0.2 mg). A typical monthly supply (30 injections) may cost between $1800 and $3600.
Ipamorelin: Vials of 1 mg can be found for $100 to $250, meaning a single dose costs roughly $10 to $25. A month’s worth of 3-time daily dosing would total around $900–$2250.
CJC-1295 with DAC: The most common 1 mg vial retails between $200 and $350. Weekly dosing (4 injections) can therefore cost about $800–$1400 per month.
Bulk purchases, subscription plans, or direct manufacturer discounts often reduce these figures by 10–20 percent. Always verify the certificate of analysis to ensure product quality before making a purchase.
Important Notice
Peptide therapies like sermorelin, ipamorelin, and CJC-1295 are prescription-grade substances in most jurisdictions. They should only be used under the supervision of a qualified healthcare provider who can monitor growth hormone levels, IGF-1, and potential side effects such as water retention, joint pain, or changes in blood sugar regulation. Self-administration without medical oversight carries risks including hormonal imbalance, injection site complications, and inadvertent contamination. Additionally, purchasing peptides from unverified online vendors may expose users to counterfeit or contaminated products that could cause serious health problems. Always seek a reputable source, confirm product authenticity through third-party testing, and maintain regular lab work while on therapy.